Garcia-Barrantes, Pedro M: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu 1 ), Based on an N -(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu 1 Receptors Found in Schizophrenics

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Niswender, Colleen M., Byers, Frank W., Locuson, Charles W., Blobaum, Anna L., Xiang, Zixiu, Rook, Jerri M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.07 MB

english, 2015

2

Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats

Cristina Herrera, Pedro M. García-Barrantes, Franklin Binns, Marianela Vargas, Luis Poveda, Sandra Badilla

Journal:

Journal of Ethnopharmacology

Year:

2011

Language:

english

File:

PDF, 414 KB

english, 2011

3

Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models

Pedro Manuel García-Barrantes, Beatriz Badilla

Journal:

Journal of Ethnopharmacology

Year:

2011

Language:

english

File:

PDF, 383 KB

english, 2011

4

Diverse Effects on M 1 Signaling and Adverse Effect Liability within a Series of M 1 Ago-PAMs

Rook, Jerri M., Abe, Masahito, Cho, Hyekyung P., Nance, Kellie D., Luscombe, Vincent B., Adams, Jeffrey J., Dickerson, Jonathan W., Remke, Daniel H., Garcia-Barrantes, Pedro M., Engers, Darren W., Eng

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

5

Chemical Modulation of Mutant mGlu 1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Brogan, John T., Hopkins, Corey R., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Bubser, Michael, Daniels, J. Scott,

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.29 MB

english, 2014

6

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.99 MB

english, 2016

7

Total Synthesis of Actinophenanthroline A

Garcia-Barrantes, Pedro M., Harp, Joel R., Lindsley, Craig W.

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 707 KB

english, 2016

8

A novel M1 PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity

Rook, Jerri M., Bertron, Jeanette L, Cho, Hyekyung P., Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel,

Journal:

ACS Chemical Neuroscience

Year:

2018

Language:

english

File:

PDF, 962 KB

english, 2018

9

The discovery of VU0486846: Steep SAR from a series of M 1 PAMs based on a novel benzomorpholine core

Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Salovich, James M., Nance, Kellie D., Engers, Darren W., Rook, Jerri M., Blobaum, Anna L., Niswender, Colleen M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 983 KB

english, 2018

10

Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4)

Engers, Darren W., Blobaum, Anna L., Gogliotti, Rocco D., Cheung, Yiu-Yin, Salovich, James M., Garcia-Barrantes, Pedro M., Daniels, J. Scott, Morrison, Ryan, Jones, Carrie K., Soars, Matthew G., Zhuo,

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

11

Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

Panarese, Joseph D., Cho, Hykeyung P., Adams, Jeffrey J., Nance, Kellie D., Garcia-Barrantes, Pedro M., Chang, Sichen, Morrison, Ryan D., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 983 KB

english, 2016

12

One pot synthesis of unsymmetrical ketones from carboxylic and boronic acids via PyClU-mediated acylative Suzuki coupling

Garcia-Barrantes, Pedro M., McGowan, Kevin, Ingram, Steven W., Lindsley, Craig W.

Journal:

Tetrahedron Letters

Year:

2017

Language:

english

File:

PDF, 416 KB

english, 2017

13

Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators

Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F

Journal:

Molecular Psychiatry

Year:

2018

Language:

english

File:

PDF, 3.72 MB

english, 2018

14

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

15

Re-exploration of the mGlu1 PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Starr, Tahj M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.32 MB

english, 2016

16

Total Synthesis of Gombamide A

Garcia-Barrantes, Pedro M., Lindsley, Craig W.

Journal:

Organic Letters

Year:

2016

Language:

english

File:

PDF, 596 KB

english, 2016

17

Synthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agents

García-Barrantes, Pedro M., Lamoureux, Guy V., Pérez, Alice L., García-Sánchez, Rory N., Martínez, Antonio R., San Feliciano, Arturo

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.15 MB

english, 2013

18

Discovery of VU0409551/JNJ-46778212: An mGlu 5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 973 KB

english, 2015

19

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Metts, Adam M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 3.20 MB

english, 2016

20

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Gogliotti, Rocco D., Engers, Darren W., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Gentry, Patrick R., Blobaum, Anna L., Morrison, Ryan D., Daniels, J. Scott, Thompson, Analisa D., Jones, Carrie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.21 MB

english, 2016

21

ChemInform Abstract: Total Synthesis of Actinophenanthroline A.

Garcia-Barrantes, Pedro M., Harp, Joel R., Lindsley, Craig W.

Journal:

Year:

2016

File:

PDF, 14 KB

2016

22

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

File:

PDF, 2.99 MB

2016

23

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P., Garcia-Barrantes, Pedro M., Camper, DeMarco, Chauder, Brian A., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.41 MB

english, 2013

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски